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11.
An association between a lymphocyte antigen in sheep and the response to vaccination against the parasite Trichostrongylus colubriformis 总被引:1,自引:0,他引:1
Lymphocyte antigens were tested in sheep which had been selected for responsiveness to vaccination against the intestinal nematode Trichostrongylus colubriformis. These sheep had been bred in an assortative mating programme which produced offspring designated as either “high responders” or “low responders”, with highly heritable resistance or susceptibility.Ovine lymphocyte antigen (OLA) typing antisera were obtained from parous ewes in the course of matings which produced the high and low responder flocks. A particular antigen (SY1) was found to be present in high frequency on the lymphocytes of high responder (72·2%) and in lower frequency (21·9%) on the lymphocytes of low responder rams. In ewes, the frequency for high responders was 65·7% and for low responders it was 33·5%. A similar association between the SY1 antigen and low faecal egg count was found in random-bred sheep which had been vaccinated with irradiated larvae and challenged with normal larvae. The conclusion was drawn that this lymphocyte antigen was likely to be part of the sheep major histocompatibility complex which influenced the immune response of sheep to vaccination against the parasite. 相似文献
12.
Louise Bezuidenhout 《Developing world bioethics》2019,19(1):18-24
Most scientists recognize the importance of sharing data online in an open fashion. Nonetheless, many studies have documented the concerns that accompany data sharing activities, including loss of credit or IP, misuse and the time needed to curate interoperable data. To this end, discussions around data sharing often identify incentives that could potentially ameliorate these disincentivising concerns. Nonetheless, current Open Data discussions often rely on evidence‐based studies to identify the disincentives to overcome. This results in highly specific and directed interventions. In contrast, this paper offers a different interpretation of these concerns. To do so, it makes use of the Thomas Theorem which suggests that: “If men define situations as real, they are real in their consequences”. Using empirical evidence from sub‐Saharan African (bio)chemistry laboratories, this paper illustrates how individual perceptions of research environments – whether associated with evidence or not – are highly influential in shaping data sharing practices. It concludes with the suggestion that discussion on incentivising data sharing amongst scientific communities need to take a broader set of concerns into account and offer a more creative approach to ameliorating environmental disincentives. 相似文献
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JOEL B. THOMPSON HENRY T. MULLINS CATHRYN R. NEWTON THOMAS L. VERCOUTERE 《Lethaia: An International Journal of Palaeontology and Stratigraphy》1985,18(2):167-179
An abundant calcareous fauna has been discovered in the oxygen minimum zone (OMZ; < 0.5 ml/l O2 ) off central California at oxygen concentrations considerably less than those predicted by previous ecological models. Analysis of box core samples and bottom photographs has revealed a distinct depth zonation of echinoderms. Asteroids and ophiuroids are most abundant along the upper and lower edges of the OMZ, respectively, whereas echinoids are found near the core of this zone where oxygen levels are as low as 0.3 ml/l O2 . As these heart urchins are very abundant (14/m2 ), they represent a potentially significant component of the fossil record of OMZ's. Locally these urchins are capable of disturbing over 90% of near surface sediment. The core of the OMZ is inhabited by hermit crabs that actively transport and recycle gastropod shells. This 'biotransport' results in an accumulation of potentially preservable, non-endemic. hard-bodied organisms which may lead to misinterpretation of paleo-oxygenation conditions. We propose an alternative to the Rhoads & Morse (1971, Lethaia 4 ) biofacies model for open-ocean, dysaerobic environments which consists of: (1) a zone devoid of maeroinvertebrates. characterized by laminated sediments (<0.1 ml/l O2 ); (2) a zone dominated by small (1–2 mm) soft-bodied infauca which exhibits moderate disturbance of laminae due to bioturbation (0.1–0.3 ml/l O2 ); and (3) a zone inhabited by an abundant calcareous fauna characterized by highly bioturbated sediments (>0.3 ml/l O2 ). 相似文献
14.
Concentrations of soluble aluminum (Al) and manganese (Mn) frequently reach phytotoxic levels in acid soils. While dose response relationships for these metals are well documented, the effects of combined exposure have received less attention. We have examined the effect of combinations of Al and Mn on growth and metal accumulation in Vigna unguiculata (L.) Walp. grown in solution culture under conditions of low ionic strength (conductivities typically < 100 µS cm−1 ). The nature of interaction between these metals varied with the specific physiological response, the part of the plant investigated, and the relative amount of stress imposed. Analysis of growth data provided evidence for amelioration of metal toxicity (antagonistic effects), although this effect was dose dependent. Analysis of metal content data provided evidence for antagonistic and synergistic (exacerbation of toxicity) effects, again depending on dose. Analysis of foliar symptoms also provided evidence for antagonisms and synergisms, with the nature of the response dependent on the specific physiological response and specific plant part investigated. In contrast with previous reports, evidence for antagonistic, synergistic, and multiplicative effects on growth, metal uptake, and expression of foliar symptoms have been obtained under physiologically and environmentally relevant conditions. These results suggest a more detailed analysis of the potential for interactions between metals in the environment is required. 相似文献
15.
Alterations in the lumbo-pelvic coordination denote changes in neuromuscular control of trunk motion as well as load sharing between passive and active tissues in the lower back. Differences in timing and magnitude aspects of lumbo-pelvic coordination between patients with chronic low back pain (LBP) and asymptomatic individuals have been reported; yet, the literature on lumbo-pelvic coordination in patients with acute LBP is scant. A case-control study was conducted to explore the differences in timing and magnitude aspects of lumbo-pelvic coordination between females with (n=19) and without (n=19) acute LBP. Participants in each group completed one experimental session wherein they performed trunk forward bending and backward return at preferred and fast paces. The amount of lumbar contribution to trunk motion (as the magnitude aspect) as well as the mean absolute relative phase (MARP) and deviation phase (DP) between thoracic and pelvic rotations (as the timing aspect) of lumbo-pelvic coordination were calculated. The lumbar contribution to trunk motion in the 2nd and the 3rd quarters of both forward bending and backward return phases was significantly smaller in the patient than the control group. The MARP and the DP were smaller in the patient vs. the control group during entire motion. The reduced lumbar contribution to trunk motion as well as the more in-phase and less variable lumbo-pelvic coordination in patients with acute LBP compared to the asymptomatic controls is likely the result of a neuromuscular adaptation to reduce painful deformation and to protect injured lower back tissues. 相似文献
16.
In three field experiments carried out during 1989-91, a permanent sward of pure white clover (Trifolium repens) was established to provide a source of N for winter or spring wheat crops (Triticum vulgare) directly drilled into the legume. Spring-sown wheat failed to compete with the clover, but wheat sown in the autumn established successfully. N fertiliser was applied to all three experiments at rates of 0, 50 and 100 kg N ha“1 measurements of grain and whole-crop silage yields were made. Yields were low for all treatments, probably because of the dry conditions prevailing and the low soil N status of the site used. Yield responses to fertiliser were significant, despite the contribution to plant nutrition that the clover was intended to make. A key feature of the work was that the clover survived successive cereal crops and could be grazed and used as an understorey for later crops. Further, response to fertiliser N diminished with a successive crop implying a build-up of available soil N, which measurements confirmed had occurred. Use of the system obviated the need to use pesticides, although reasons for the lack of pest damage were not clear. 相似文献
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